Similar immune mechanisms control experimental airway eosinophilia elicited by different allergens and treatment protocols.
Evelyn J HydeKirsty A WakelinNaomi J DanielsSayani GhoshFranca RonchesePublished in: BMC immunology (2019)
All the models studied were comparably dependent on adaptive CD4+ T cell responses and TSLP. In contrast, sex, NKT cells and TLR4 appeared to play subtler and more variable roles that were dependent on the type of allergen and mode of immunization and challenge. These results are consistent with clinical data suggesting a key role of CD4+ T cells and TSLP in patients with allergic asthma.
Keyphrases
- allergic rhinitis
- induced apoptosis
- chronic obstructive pulmonary disease
- cell cycle arrest
- magnetic resonance
- inflammatory response
- toll like receptor
- immune response
- lung function
- big data
- oxidative stress
- magnetic resonance imaging
- endoplasmic reticulum stress
- computed tomography
- combination therapy
- air pollution
- deep learning
- data analysis
- artificial intelligence
- smoking cessation
- replacement therapy