Enhanced Cardiac CaMKII Oxidation and CaMKII-Dependent SR Ca Leak in Patients with Sleep-Disordered Breathing.
Michael ArztMarzena A DrzymalskiSarah RipfelSebastian MeindlAlexander BiedermannMelanie DurczokKaroline KellerJulian MustrophSylvia KatzMaria TafelmeierSimon LebekBernhard FlörchingerDaniele CamboniSigrid WittmannJohannes BacksChristof SchmidLars Siegfried MaierStefan WagnerPublished in: Antioxidants (Basel, Switzerland) (2022)
Patients with SDB have increased CaMKII oxidation/activation and increased CaMKII-dependent CaSpF in the atrial myocardium, independent of major clinical confounders, which may be a novel target for treatment of atrial arrhythmias in SDB.