Guilu-Erxian-Glue alleviates Tripterygium wilfordii polyglycoside-induced oligoasthenospermia in rats by resisting ferroptosis via the Keap1/Nrf2/GPX4 signaling pathway.

Jin DingBaowei LuLumei LiuZixuan ZhongNeng WangBonan LiWen ShengQinghu He

Published in: Pharmaceutical biology (2023)

Ferroptosis resistance from GLEXG might be driven by activation of the Keap1/Nrf2/GPX4 pathway. Targeting ferroptosis is a novel approach for OAS therapy.

Keyphrases

cell death
oxidative stress
signaling pathway
diabetic rats
high glucose
protein protein
pi k akt
epithelial mesenchymal transition
cancer therapy
stem cells
induced apoptosis
mouse model
drug delivery
mesenchymal stem cells
bone marrow
smoking cessation