Two new terpenoids with anti-inflammatory activity from the fruits of Arenga pinnata (Wurmb) Merr.
Jia-Tong WuAdnan Mohammed AlgradiYan LiuJin-Hai HuoXiao-Mao LiBing-You YangWei-Ming WangPublished in: Natural product research (2022)
Two new terpenoids ( 1 and 2 ), arenterpenoid D ( 1 ) and pinnasesquiterpene A ( 2 ), along with 16 phenylpropanoids ( 3 - 18 ) and 8 known terpenoids ( 19 - 26 ) were isolated from 70% EtOH extract of the Arenga pinnata (Wurmb) Merr. fruits. Their structures were elucidated by spectroscopic methods including HR-ESI-MS, 1D, and 2D NMR. The absolute configuration of arenterpenoid D ( 1 ) was defined by X-ray crystallographic analysis. Furthermore, we evaluated the anti-inflammatory activity of all compounds, and outcomes showed that 2 and 21 exposed moderate suppressive effects against NO generation in lipopolysaccharide-stimulated RAW 264.7 cells.
Keyphrases
- high resolution
- ms ms
- induced apoptosis
- mass spectrometry
- cell cycle arrest
- magnetic resonance
- multiple sclerosis
- oxidative stress
- molecular docking
- inflammatory response
- toll like receptor
- high intensity
- lps induced
- anti inflammatory
- endoplasmic reticulum stress
- solid state
- immune response
- data analysis
- electron microscopy