Cardiac wasting in head and neck cancer and in cardiac autopsies from different cancer types: A study in a chemo-naïve setting.
Sara CalamelliSamantha NotoAlessandra BaldoniAlessandra CasarinAlessandro CalzavaraIrene BolganSilvia CoccatoSalvatore SaccàLicia LaurinoGiuseppe AzzarelloSimonetta AusoniPublished in: Journal of cachexia, sarcopenia and muscle (2023)
Subtle changes in heart structure and function occur early in HNC patients. These can be detected with routine echocardiography and may help to select appropriate cancer treatment regimens for these patients. Histopathological analysis provided conclusive evidence that atrophy of cardiomyocytes, oedema and fibrosis occur during cancer progression and may precede the onset of overt cardiac pathology. To our knowledge, this is the first clinical study that establishes a direct relationship between tumour progression and cardiac remodelling in HNCs and the first pathological study conducted on human cardiac autopsies from selected chemo-naïve cancer patients.
Keyphrases
- left ventricular
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- papillary thyroid
- prognostic factors
- heart failure
- peritoneal dialysis
- healthcare
- computed tomography
- photodynamic therapy
- atrial fibrillation
- locally advanced
- lymph node metastasis
- pulmonary hypertension
- patient reported
- double blind
- young adults
- childhood cancer
- data analysis