Hydrogen: A Novel Option in Human Disease Treatment.
Mengling YangYinmiao DongQingnan HePing ZhuQuan ZhuangJie ShenXueyan ZhangMing-Yi ZhaoPublished in: Oxidative medicine and cellular longevity (2020)
H2 has shown anti-inflammatory and antioxidant ability in many clinical trials, and its application is recommended in the latest Chinese novel coronavirus pneumonia (NCP) treatment guidelines. Clinical experiments have revealed the surprising finding that H2 gas may protect the lungs and extrapulmonary organs from pathological stimuli in NCP patients. The potential mechanisms underlying the action of H2 gas are not clear. H2 gas may regulate the anti-inflammatory and antioxidant activity, mitochondrial energy metabolism, endoplasmic reticulum stress, the immune system, and cell death (apoptosis, autophagy, pyroptosis, ferroptosis, and circadian clock, among others) and has therapeutic potential for many systemic diseases. This paper reviews the basic research and the latest clinical applications of H2 gas in multiorgan system diseases to establish strategies for the clinical treatment for various diseases.
Keyphrases
- endoplasmic reticulum stress
- cell death
- anti inflammatory
- oxidative stress
- clinical trial
- induced apoptosis
- endothelial cells
- ejection fraction
- systematic review
- cell cycle arrest
- end stage renal disease
- signaling pathway
- carbon dioxide
- cell proliferation
- nlrp inflammasome
- intensive care unit
- ionic liquid
- phase iii
- human health
- respiratory failure