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Acute kidney injury in a mouse model of meningococcal disease.

Karin R KolbeTalita R SanchesCamilla FanelliMargoth R GarnicaLetícia Urbano de CastroKaren GoochStephen R ThomasStephen TaylorAndrew GorringeIrene de L NoronhaLucia Andrade
Published in: International journal of immunopathology and pharmacology (2022)
Our findings corroborate those of other studies of AKI in sepsis. To our knowledge, this is the first time that meningococci have been identified in renal interstitium and that the resulting apoptosis and inflammation have been evaluated. However, additional studies are needed in order to elucidate the mechanisms involved.
Keyphrases
  • oxidative stress
  • mouse model
  • acute kidney injury
  • case control
  • healthcare
  • intensive care unit
  • endoplasmic reticulum stress
  • cell death
  • septic shock
  • cell cycle arrest