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Deciphering the mechanisms of the IL-6/CXCL1 and NOD-like receptor signaling pathways in otitis media with effusion in rodents.

Yixuan LiuTingting QianNanfeng ZhangJiazhen CaoXiaoling LuQiling TongXinyuan WangHuawei LiShan SunHuiqian Yu
Published in: International immunopharmacology (2024)
Our findings confirm that IL-6 and CXCL1 play significant roles in the innate immune response in OME in rodents, predominantly via the NOD-like receptor signaling pathway and NLRP3 inflammasome activation. This research sheds light on OME pathogenesis and its immune-related mechanisms.
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