BRCC3 Regulation of ALK2 in Vascular Smooth Muscle Cells: Implication in Pulmonary Hypertension.
Hui ShenYa GaoDedong GeMeng TanQing YinTong-You Wade WeiFangzhou HeTzong-Yi LeeZhongyan LiYuqin ChenQifeng YangZhangyu LiuXinxin LiZixuan ChenYi YangZhengang ZhangPatricia A ThistlethwaiteJian WangAtul MalhotraJason X-J YuanJohn Y-J ShyyKaizheng GongPublished in: Circulation (2024)
These results suggest a pivotal role of BRCC3 in sustaining pulmonary vascular homeostasis by maintaining the integrity of the BMP signaling (ie, the ALK2-Smad1/5-PPARγ axis) while suppressing TGF-β signaling in PASMCs. Such rebalance of BMP/TGF-β pathways is translationally important for PAH alleviation.
Keyphrases
- pulmonary hypertension
- vascular smooth muscle cells
- transforming growth factor
- mesenchymal stem cells
- angiotensin ii
- epithelial mesenchymal transition
- advanced non small cell lung cancer
- pulmonary artery
- pulmonary arterial hypertension
- signaling pathway
- bone regeneration
- insulin resistance
- type diabetes
- skeletal muscle
- bone marrow