TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy.
Dengqiu XuSijia LiLu WangJingwei JiangLei ZhaoXiaofei HuangZeren SunChunjie LiLixin SunXihua LiZhen-Zhou JiangLuyong ZhangPublished in: Journal of cachexia, sarcopenia and muscle (2020)
Our findings show that TAK1 activation exacerbated fibrosis and muscle degeneration and that TAK1 inhibition can improve whole-body muscle quality and the function of dystrophic skeletal muscle. Thus, TAK1 inhibition may constitute a novel therapy for DMD.