Intranasal insulin administration decreases cerebral blood flow in cortico-limbic regions: A neuropharmacological imaging study in normal and overweight males.
Jed O WingroveOwen O'DalyBen ForbesMagda SwedrowskaStephanie A AmielFernando O ZelayaPublished in: Diabetes, obesity & metabolism (2020)
Insulin-induced changes within key regions of the brain involved in gustation, memory and reward were observed in overweight healthy male individuals. Following placebo administration, differences in gustatory rCBF were observed between overweight and normal weight healthy individuals.
Keyphrases
- weight loss
- weight gain
- physical activity
- cerebral blood flow
- type diabetes
- glycemic control
- body mass index
- high resolution
- high glucose
- working memory
- white matter
- clinical trial
- resting state
- mass spectrometry
- oxidative stress
- skeletal muscle
- brain injury
- blood brain barrier
- subarachnoid hemorrhage
- insulin resistance
- photodynamic therapy
- double blind