An Inhibitory Single-Domain Antibody against Protein Z-Dependent Protease Inhibitor Promotes Thrombin Generation in Severe Hemophilia A and FXI Deficiency.

Claire AuditeauTung-Son NguyenFloriane DevauxFrançois SallerIvan PeyronAdeline BlandinièresChristelle RepérantSadyo DaraméCécile V DenisPeter LentingDelphine BorgelElsa P Bianchini

Published in: Thrombosis and haemostasis (2024)

ZPI-sdAb2 is the first specific, direct ZPI inhibitor found to exhibit procoagulant activity in plasma. This sdAb might have potential as a treatment for hemophilia or other bleeding disorders.

Keyphrases

atrial fibrillation
early onset
protein protein
human health
combination therapy
risk assessment
climate change