Streamlined downstream process for efficient and sustainable (Fab')2 antivenom preparation.
Tihana KurtovićMarija BrglesMaja Lang BalijaStephanie SteinbergerDora SvibenMartina Marchetti-DeschmannBeata HalassyPublished in: The journal of venomous animals and toxins including tropical diseases (2020)
A highly streamlined mode for production of equine F(ab')2 antivenom was engineered. In addition to preservation of the highest process yield and fulfillment of the regulatory demands, performance simplicity and rapidity in the laboratory setting were demonstrated. Suitability for large-scale manufacturing appears promising.