Effects of antifungal stewardship using therapeutic drug monitoring in voriconazole therapy on the prevention and control of hepatotoxicity and visual symptoms: A multicentre study conducted in Japan.
Yukihiro HamadaTakashi UedaYoshitsugu MiyazakiKazuhiko NakajimaKeiko FukunagaTaiga MiyazakiNana Nakada-MotokawaMiki NagaoHideki KawamuraAkari ShigemiFumiya EbiharaToshimi KimuraKazuhiro IkegameMotoi UchinoHiroki IkeuchiYoshio TakesuePublished in: Mycoses (2020)
A significant preventive effect was demonstrated on hepatotoxicity, but not on visual symptoms because of earlier occurrence. With treatment modification after the occurrence of AEs, most patients completed therapy.