Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells.
Taehyung KimHa Na HyunRoun HeoKeonwook NamKyungjik YangYoung Min KimYoon Suk LeeJae Yoon AnJae Hyung ParkSeung Young ChoiYoung Hoon RohPublished in: Chemical communications (Cambridge, England) (2021)
A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes: rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer-specific intracellular delivery, gene knockdown efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands.