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Target temperature management following cardiac arrest: a systematic review and Bayesian meta-analysis.

Anders ÅnemanSteven FrostMichael ParrMarkus B Skrifvars
Published in: Critical care (London, England) (2022)
The posterior probability distributions did not support the use of TTM at 32-34 °C compared to 36 °C also including active control of fever to reduce the risk of death and unfavourable neurological outcome at 90-180 days. Any likely benefit of hypothermic TTM is smaller than targeted in RCTs to date.
Keyphrases
  • cardiac arrest
  • systematic review
  • cardiopulmonary resuscitation
  • meta analyses
  • cancer therapy
  • case control
  • drug delivery
  • cerebral ischemia