TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism.
Armando Andres Roca SuarezMarie-Laure PlissonnierXavier GrandMaud MicheletGuillaume GiraudMaria Saez-PalmaAnaëlle DuboisSarah HeintzAudrey DiederichsNicolaas Van RenneThomas VanwolleghemStephane DaffisLi LiNikita KolhatkarYao-Chun HsuJeffrey J WallinAudrey H LauSimon P FletcherMichel RivoireMassimo LevreroBarbara TestoniFabien ZoulimPublished in: Gut (2024)
Our transcriptomic characterisation of SLGN sheds light into the programmes regulating KC activation. Furthermore, in addition to its previously described effect on established HBV infection and adaptive immunity, we show that SLGN impairs HBV entry. Altogether, SLGN may contribute through KCs to remodelling the intrahepatic immune microenvironment and may thus represent an important component of future combinations to cure HBV infection.