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Whole Genome Scan Uncovers Candidate Genes Related to Milk Production Traits in Barka Cattle.

Wondossen AyalewXiaoyun WuGetinet Mekuriaw TarekegnTesfaye Sisay TesemaRakan NaboulsiRenaud Van DammeErik Bongcam-RudloffZewdu EdeaMin ChuSolomon EnquahoneChunnian LiangPing Yan
Published in: International journal of molecular sciences (2024)
In this study, our primary aim was to explore the genomic landscape of Barka cattle, a breed recognized for high milk production in a semi-arid environment, by focusing on genes with known roles in milk production traits. We employed genome-wide analysis and three selective sweep detection methods ( ZF ST , θπ ratio, and ZHp ) to identify candidate genes associated with milk production and composition traits. Notably, ACAA1 , P4HTM , and SLC4A4 were consistently identified by all methods. Functional annotation highlighted their roles in crucial biological processes such as fatty acid metabolism, mammary gland development, and milk protein synthesis. These findings contribute to understanding the genetic basis of milk production in Barka cattle, presenting opportunities for enhancing dairy cattle production in tropical climates. Further validation through genome-wide association studies and transcriptomic analyses is essential to fully exploit these candidate genes for selective breeding and genetic improvement in tropical dairy cattle.
Keyphrases
  • genome wide
  • computed tomography
  • climate change
  • genome wide analysis
  • copy number
  • rna seq
  • genome wide association
  • magnetic resonance
  • bioinformatics analysis