Chemical constituents from the heterotrophic marine microalgae Aurantiochytrium sp. SC145 and their antimicrobial activities.
Nguyen Thi Thu ThuyHoang Thi Minh HienNguyen Cam HaLe Thi ThomDang Diem HongNguyen Van ThinhNguyen Trong DanNguyen Dang HoiVu Thi LoanHoang Duc QuangDan Thi Thuy HangPhan Van KiemBui Huu TaiNguyen Thi Minh HangNguyen Tien DatNguyen Xuan NhiemPublished in: Natural product research (2023)
One new indol, N -methoxymethyltryptophol ( 1 ), one new phenolic, (2 R )-2-(4-hydroxyphenyl)ethyl 2-hydroxy-3-phenylpropanoate ( 2 ) and fifteen known compounds ( 3-17 ) were isolated from the methanol extract of the fermentation of marine microalgae Aurantiochytrium sp. SC145. Their structures were elucidated by 1D-, 2D-NMR spectroscopic analysis, HR-ESI-MS, quantum chemical calculation methods and by comparing their NMR data with those reported in the literature. All compounds were evaluated for their antimicrobial activities against microorganisms. Compounds 2, 3 and 11 significantly exhibited antimicrobial activities on all tested Gram-(+), Gram-(-) bacteria and the yeast C. albicans with MIC values ranging from 32 to 256 µg/mL.
Keyphrases
- staphylococcus aureus
- high resolution
- gram negative
- ms ms
- magnetic resonance
- systematic review
- multiple sclerosis
- saccharomyces cerevisiae
- mass spectrometry
- molecular docking
- oxidative stress
- multidrug resistant
- candida albicans
- machine learning
- ionic liquid
- deep learning
- anti inflammatory
- data analysis
- artificial intelligence
- molecular dynamics simulations
- energy transfer