Insights into the eradication of drug resistant Staphylococcus aureus via compound 6-nitrobenzo[ cd ]indole-2(1 H )-ketone.

6-Nitrobenzo[ cd ]indole-2(1 H )-ketone (compound C2) exhibits an excellent germicidal effect against methicillin-resistant Staphylococcus aureus (MRSA). Mechanism studies show that C2 induces ROS over-production, cell membrane damage, and ATP and virulence factor down-regulation in bacteria. More importantly, C2 can inhibit biofilm formation and accelerate wound healing in a mouse infection model induced by MRSA.