Global treatment rate and barriers to direct-acting antiviral therapy: A systematic review and meta-analysis of 146 studies and 1 760 352 hepatitis C virus patients.

Vy H NguyenDaniel Q HuangMichael H LeMichelle JinEunice Y LeeLinda HenrySanjna N NerurkarEiichi OgawaKhin N ThinMargaret L P TengKang S GohJustin C Y KaiConnie WongDarren J H TanLe T T ThuyHoang HaiMasaru EnomotoRamsey C Cheung Mindie H Nguyen

Published in: Liver international : official journal of the International Association for the Study of the Liver (2023)

Though a marked improvement from IFN/DAA, the treatment rate with IFN-free DAA remains suboptimal (52.3% overall, 32.3% in HCC patients). Non-adherence to clinical follow-up and lack of disease awareness were treatment barriers.

Keyphrases

end stage renal disease
hepatitis c virus
ejection fraction
chronic kidney disease
immune response
prognostic factors
type diabetes
patient reported outcomes
human immunodeficiency virus
skeletal muscle
patient reported
hiv infected