Topical cutaneous application of CO2 accelerates bone healing in a rat femoral defect model.

Yu KuroiwaTomoaki FukuiShunsuke TakaharaSang Yang LeeKeisuke OeMichio ArakuraYohei KumabeTakahiro OdaTomoyuki MatsumotoTakehiko MatsushitaToshihiro AkisueYoshitada SakaiRyosuke KurodaTakahiro Niikura

Published in: BMC musculoskeletal disorders (2019)

Topical cutaneous application of CO2 accelerated bone healing in a rat femoral defect model. CO2 application can be a novel and useful therapy for accelerating bone healing in bone defects; further research on its efficacy in humans is warranted.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
oxidative stress
body composition
wound healing