Molecular Classification of Appendiceal Adenocarcinoma.

Michael B Foote Henry S Walch Walid K ChatilaEfsevia VakianiChris ChandlerFelix SteinrueckeGarrett M NashZsofia K Stadler Sebastian K Chung Rona Yaeger Maria Ignez Freitas Melro Braghiroli Jinru Shia Yelena M KemelAnna MaioMargaret SheehanBenoit Rousseau Guillem Argilés Michael F Berger David B Solit Nikolaus Schultz Luis A Diaz Andrea Cercek

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)

AC molecular patterns identify distinct molecular subtypes: a clinically indolent RAS-mut/GNAS-wt/TP53-wt subtype; a chemotherapy-resistant GNAS-mut predominant subtype; and an aggressive, highly aneuploid TP53-mut predominant subtype. Each subtype exhibits conserved clinical behavior irrespective of histopathology.

Keyphrases

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