Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.

Austin L BrownPagna SokKimberly P RaghubarPhilip J LupoMelissa A RichardAlanna C MorrisonJun J YangClinton F StewartM Fatih OkcuMurali M ChintagumpalaAmar GajjarLisa S KahalleyHeather ConklinMichael E Scheurer

Published in: Neuro-oncology (2023)

Inherited genetic variants involved in baseline cognitive functioning and novel susceptibility loci jointly influence the degree of treatment-associated cognitive decline in pediatric CNS tumor survivors.

Keyphrases

cognitive decline
mild cognitive impairment
genome wide
young adults
blood brain barrier
combination therapy
radiation induced
copy number