The potential regulatory role of hsa_circ_0004104 in the persistency of atrial fibrillation by promoting cardiac fibrosis via TGF-β pathway.

Yuanfeng GaoYe LiuYuan FuQianhui WangZheng LiuRoumu HuXinchun YangMulei Chen

Published in: BMC cardiovascular disorders (2021)

CircRNAs dysregulation plays vital roles in AF persistency. hsa_circ_0004104 could be a potential regulator and biomarker in AF persistency by promoting cardiac fibrosis via targeting MAPK and TGF-beta pathways.

Keyphrases

atrial fibrillation
transforming growth factor
left ventricular
transcription factor
left atrial
oral anticoagulants
catheter ablation
left atrial appendage
heart failure
signaling pathway
direct oral anticoagulants
oxidative stress
human health
cancer therapy
liver fibrosis
epithelial mesenchymal transition