Senescent cell population with ZEB1 transcription factor as its main regulator promotes osteoarthritis in cartilage and meniscus.

Hannah SwahnKun LiTomas DuffyMerissa OlmerDarryl D D'LimaTony S MondalaPadmaja NatarajanSteven R HeadMartin K Lotz

Published in: Annals of the rheumatic diseases (2022)

These single-cell studies identified a senescent pathogenic cell cluster that is present in cartilage and meniscus and has FAP and ZEB1 as main regulators which are novel and promising therapeutic targets for OA-associated pathways in both tissues.

Keyphrases

single cell
transcription factor
rna seq
epithelial mesenchymal transition
long non coding rna
gene expression
high throughput
rheumatoid arthritis
stem cells
mesenchymal stem cells