Prenatal DNA Sequencing: Clinical, Counseling, and Diagnostic Laboratory Considerations.
Ahmad N Abou TayounNancy B SpinnerHeidi L RehmRobert C GreenDiana W BianchiPublished in: Prenatal diagnosis (2017)
Clinical diagnostic laboratories are producing next-generation sequencing-based test results that are becoming increasingly incorporated into patient care. Whole genome and exome sequencing on fetal material derived from amniocytes, chorionic villi, or products of conception is starting to be offered clinically in specialized centers, but it has not yet become routine practice. The technical, interpretation, and ethical challenges are greatest in the area of prenatal medicine because the fetus has a limited health history, and the physical examination is only indirectly available via prenatal sonography. Here, we provide an overview of these challenges and highlight the clinical utility, reporting, and counseling issues associated with prenatal DNA sequencing. Future considerations are also discussed. © 2017 John Wiley & Sons, Ltd.
Keyphrases
- pregnant women
- circulating tumor
- single cell
- healthcare
- mental health
- single molecule
- cell free
- primary care
- public health
- palliative care
- physical activity
- smoking cessation
- magnetic resonance imaging
- computed tomography
- current status
- gene expression
- decision making
- quality improvement
- magnetic resonance
- hepatitis c virus
- hiv testing
- hiv infected
- human immunodeficiency virus
- risk assessment
- antiretroviral therapy