APOE ε4 is associated with decreased synaptic density in cognitively impaired participants.

Kun HeBinyin LiJie WangYing WangZhiwen YouXing ChenHaijuan ChenJunpeng LiQi HuangQihao GuoYiyun Henry HuangYihui GuanKewei ChenJun ZhaoYulei DengFang Xie

Published in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)

The APOE ε4 allele was associated with decreased synaptic density in CI individuals and may be driven by AD biomarkers.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
prefrontal cortex
adipose tissue
insulin resistance