More Velcro for the TGF-β1 straitjacket: A new antibody straps latent TGF-β1 to the matrix.

Published in: Science signaling (2024)

In this issue of Science Signaling , Jackson et al. present a new antibody strategy to-quite literally-strap transforming growth factor-β1 (TGF-β1) to latent complexes in the extracellular matrix. The antibody has no effect on latent TGF-β1 presented on the surface of immune cells and thus allows targeting of the detrimental effects of TGF-β1 in fibrosis without affecting its beneficial immune-suppressing activities.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
extracellular matrix
signaling pathway
public health
drug delivery