Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy.

Cenglin XuShuo ZhangYiwei GongJiazhen NaoYujia ShenBei TanShuheng XuSunliang CuiYeping RuanShuang WangYi WangZhong Chen

Published in: Annals of neurology (2021)

These results support the subicular caspase-1-interleukin-1β inflammatory pathway as a novel alternative mechanism hypothesis for pharmacoresistant TLE, and present caspase-1 as a potential target. ANN NEUROL 2021;90:377-390.

Keyphrases

cell death
induced apoptosis
temporal lobe epilepsy
oxidative stress
endoplasmic reticulum stress
signaling pathway
risk assessment
human health