Login / Signup

Gold-Catalyzed Hydrohydrazidation of Terminal Alkynes.

Dmitry P ZiminDmitry V Dar'inValentin A RassadinVadim Yu Kukushkin
Published in: Organic letters (2018)
Facile gold-catalyzed hydrohydrazidation of alkynes with various hydrazides R2CONHNH2 (R = Alk or Ar; including those with an additional nucleophilic moiety) in the presence of Ph3PAuNTf2 (6 mol %) leading to a wide range of substituted keto- N-acylhydrazones (18 examples) in excellent to good yields (99-66%) is reported. This novel metal-catalyzed coupling proceeds under mild conditions (chlorobenzene, 60 °C), exhibits high functional group tolerance, and is insensitive to the electronic and steric effects of the substituents in the reactants.
Keyphrases
  • room temperature
  • ionic liquid
  • molecular docking
  • advanced non small cell lung cancer
  • quantum dots
  • reduced graphene oxide
  • gold nanoparticles