Cell-based serum anticholinergic activity assay and working memory in cognitively healthy older adults before and after scopolamine: An exploratory study.

Susmita ChandramouleeshwaranZaid GhazalaJosé N NobregaRoger RaymondSara GambinoBruce G PollockTarek K Rajji

Published in: Journal of psychopharmacology (Oxford, England) (2022)

In our sample of cognitively healthy older adults, the new cSAA assay was able to quantify the scopolamine induced increase in anticholinergic load which correlated significantly with the observed decline in working memory and executive function.

Keyphrases

working memory
high throughput
physical activity
transcranial direct current stimulation
cognitive decline
attention deficit hyperactivity disorder
mild cognitive impairment
single cell
high glucose
diabetic rats
cell therapy
stem cells
oxidative stress
bone marrow