Near infrared low-level laser therapy and cell proliferation: The emerging role of redox sensitive signal transduction pathways.
Mario MigliarioMaurizio SabbatiniCarmen MortellaroFilippo RenóPublished in: Journal of biophotonics (2018)
Lasers devices are widely used in various medical fields (eg, surgery, dermatology, dentistry, rehabilitative medicine, etc.) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation, which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect. A less than optimal operational settings, in fact, could result in a null or even lethal effect. According to the first law of photobiology, light absorption requires the presence of a specific photoacceptor that after excitation could induce the activation of downstream signaling pathways. Low-level lasers operating in the red/near infrared portion of the light spectra are generally used for biostimulation purposes, a particular therapeutic application based on the radiant energy ability to induce nonthermal responses in living cells. Biostimulation process generally promotes cell survival and proliferation. Emerging evidences support a low-level laser stimulation mediated increase in "good" reactive oxygen species, able to activate redox sensitive signal transduction pathways such as Nrf-2, NF-kB, ERK which act as key redox checkpoints.
Keyphrases
- signaling pathway
- living cells
- cell proliferation
- pi k akt
- reactive oxygen species
- fluorescent probe
- gene expression
- oxidative stress
- high speed
- minimally invasive
- chronic pain
- healthcare
- mental health
- epithelial mesenchymal transition
- physical activity
- high frequency
- coronary artery bypass
- immune response
- spinal cord injury
- neuropathic pain
- radiation therapy
- atrial fibrillation
- nuclear factor
- toll like receptor
- postoperative pain