Evaluation of mid-term (6-12 months) neurotoxicity in B-cell lymphoma patients treated with CAR T cells: a prospective cohort study.

Didier MailletCatherine BelinChristine MoroniStefania CuzzubboRenata UrsuLila Sirven-VillarosRoberta Di BlasiCatherine ThieblemontAntoine F Carpentier

Published in: Neuro-oncology (2021)

In this cohort of patients treated with CD19-targeted CAR T cells, we found no evidence for neurological or cognitive toxicity, 6-12 months after treatment.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
endoplasmic reticulum stress
diffuse large b cell lymphoma
cell death
cancer therapy
brain injury
blood brain barrier