Utility of Perioperative Measurement of Cell-Free DNA and Circulating Tumor DNA in Informing the Prognosis of GI Cancers: A Systematic Review.
Phillip J HsuKhushboo SinghAnkit DhimanHunter D D WitmerChuan HeOliver S EngDaniel V T CatenacciMitchell C PosnerKiran K TuragaPublished in: JCO precision oncology (2022)
Detectable ctDNA, either preoperatively or postoperatively, and its persistence after curative surgery are associated with a greater risk of recurrence and decreased RFS in GI cancers. Thus, perioperative measurement of ctDNA may be a useful postoperative risk stratification tool and guide additional therapies.