Roles of paxillin phosphorylation in IL-3 withdrawal-induced Ba/F3 cell apoptosis.

Published in: Genes & genomics (2019)

The above results suggest that paxillin-mediated phosphorylation at Y31, Y40, Y118, and Y181 is essential for the anti-apoptotic effect of paxillin overexpression in Ba/F3 cells and contributes to the cell survival signaling pathway triggered by IL-3. Conversely, phosphorylation at S273 is involved in the negative regulation of the anti-apoptotic action of overexpressed paxillin.

Keyphrases

cell death
induced apoptosis
signaling pathway
protein kinase
cell cycle arrest
cell proliferation
pi k akt
anti inflammatory
high glucose
diabetic rats
endoplasmic reticulum stress
epithelial mesenchymal transition
transcription factor
oxidative stress