Effects of Oxytocin on Cell Proliferation in a Corticotroph Adenoma Cell Line.

Jung Soo LimYoung Woo EomEun Soo LeeHyeong Ju KwonJa Young KwonJunjeong ChoiChoon Hee ChungYoung Suk JoEun Jig Lee

Published in: Endocrinology and metabolism (Seoul, Korea) (2020)

Although the cytotoxic effect of OXT in AtT20 cells was not definite, OXT may blunt cell proliferation of corticotroph adenomas by altering the cell cycle or reducing PCNA and P-ERK levels. Further research is required to investigate the role of OXT as a potential therapeutic target in corticotroph adenomas.

Keyphrases

cell cycle
cell proliferation
pi k akt
cell cycle arrest
induced apoptosis
signaling pathway
oxidative stress
cell death
human health
risk assessment