A copper iodide-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines: an approach to α-ketoamides.

Rongxiang ChenRuo-Ling JiaWenbo LiWei ZhaoKai-Kai Wang Zhan-Yong WangXueji MaWei DaiAili Sun

Published in: Organic & biomolecular chemistry (2021)

A CuI-catalyzed coupling reaction of benzofuran-3(2H)-ones with amines has been well established for the direct synthesis of α-ketoamides. This process involves C-O bond cleavage and C[double bond, length as m-dash]O/C-N bond formation. Mechanism studies indicated that this α-ketoamide formation reaction may involve a free radical process.

Keyphrases

electron transfer
room temperature
transition metal
ionic liquid
dna binding
case control
oxide nanoparticles
solid state