Cognitive domains affected post-COVID-19; a systematic review and meta-analysis.
Jack B FanshaweBrendan F SargentJames B BadenochAman SainiCameron J WatsonAleksandra PokrovskayaDaruj AniwattanapongIsabella ContiCharles NyeElla BurchillZain U HussainKhanafi SaidElinda KuhogaKukatharmini TharmaratnamSophie PenderedBernard MbweleMaxime TaquetGreta K WoodJonathan P RogersAdam HampshireAlan CarsonAnthony S DavidBenedict D MichaelTimothy R NicholsonStella-Maria PaddickCharles E LeekPublished in: European journal of neurology (2024)
This review found moderate impairments across multiple domains of cognition in patients post-COVID-19, with no specific pattern. The reported literature was significantly heterogeneous, with a wide variety of cognitive tasks, small sample sizes and disparate initial disease severities limiting interpretability. The finding of consistent impairment across a range of cognitive tasks suggests broad, as opposed to domain-specific, brain dysfunction. Future studies should utilize a harmonized test battery to facilitate inter-study comparisons, whilst also accounting for the interactions between COVID-19, neurological sequelae and mental health, the interplay between which might explain cognitive impairment.
Keyphrases
- coronavirus disease
- sars cov
- mental health
- cognitive impairment
- end stage renal disease
- working memory
- ejection fraction
- chronic kidney disease
- newly diagnosed
- white matter
- systematic review
- respiratory syndrome coronavirus
- oxidative stress
- prognostic factors
- mild cognitive impairment
- patient reported outcomes
- mental illness