Heat shock protein 60 and cardiovascular diseases: An intricate love-hate story.
Indumathi Krishnan-SivadossIván A Mijares-RojasRamiro A Villarreal-LealGuillermo Torre-AmioneAnne A KnowltonCarlos Enrique Guerrero-BeltránPublished in: Medicinal research reviews (2020)
Cardiovascular diseases (CVDs) are the result of complex pathophysiological processes in the tissues comprising the heart and blood vessels. Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to cellular stress events including apoptosis, oxidative and shear stress, and cellular and humoral immune responses, all of which impair the system's structure and function. An intracellular chaperone, heat shock protein 60 (HSP60) is an intriguing example of a protein that may both be an ally and a foe for cardiovascular homeostasis; on one hand providing protection against cellular injury, and on the other triggering damaging responses through innate and adaptive immunity. In this review we will discuss the functions of HSP60 and its effects on cells and the immune system regulation, only to later address its implications in the development and progression of CVD. Lastly, we summarize the outcome of various studies targeting HSP60 as a potential therapeutic strategy for cardiovascular and other diseases.
Keyphrases
- heat shock protein
- immune response
- cardiovascular disease
- oxidative stress
- cell cycle arrest
- heat shock
- induced apoptosis
- cell death
- heart failure
- endoplasmic reticulum stress
- dendritic cells
- gene expression
- pi k akt
- cardiovascular risk factors
- atrial fibrillation
- metabolic syndrome
- amino acid
- coronary artery disease
- signaling pathway
- cancer therapy
- binding protein