Current Status of Our Understanding for Brain Integrated Functions and its Energetics.
Anjani Kumar TiwariAnupriya AdhikariLokesh Chandra MishraAbhishek SrivastavaPublished in: Neurochemical research (2022)
Human/animal brain is a unique organ with substantially high metabolism but it contains no energy reserve that is the reason it requires continuous supply of O 2 and energy fluxes through CBF. The main source of energy remains glucose as the other biomolecules do not able to cross the blood-brain barrier. The speed of glucose metabolism is heterogeneous throughout the brain. One of the major flux consumption is Neuron-astrocyte cycling of glutamate and glutamine in glutamatergic neurons (approximately 80% of glucose metabolism in brain). The quantification of cellular glucose and other related substrate in resting, activated state can be analyzed through [ 18 F]FDG -positron-emission tomography (studying CMRglc) and [ 13 C/ 31 P -MRS: for neuroenergetics & neurotransmitter cycling & 31 P-MRS: for energy induction & redox state). Merging basic in vitro studies with these techniques will help to develop new treatment paradigms for human brain diseased conditions.
Keyphrases
- positron emission tomography
- resting state
- white matter
- computed tomography
- functional connectivity
- current status
- pet ct
- endothelial cells
- pet imaging
- spinal cord
- high intensity
- blood glucose
- heart rate
- type diabetes
- adipose tissue
- smoking cessation
- heart rate variability
- weight loss
- insulin resistance
- combination therapy
- drug induced
- amino acid