Bridging thrombolysis in atrial fibrillation stroke is associated with increased hemorrhagic complications without improved outcomes.
Feras AkbikAli M AlawiehLaurie DimiskoBrian M HowardC Michael CawleyFrank C TongFadi NahabOwen B SamuelsIlko L MaierWuwei FengNitin GoyalRobert M StarkeAnsaar RaiKyle M FargenMarios N PsychogiosPascal M JabbourReade De LeacySaleh G KeyrouzTravis M DumontPeter T KanJan LimanAdam S ArthurStacey Quintero WolfeJ D MoccoRoberto Javier CrosaW Christopher FoxBenjamin GoryAlejandro M SpiottaJonathan A Grossbergnull nullPublished in: Journal of neurointerventional surgery (2021)
In this large thrombectomy registry, AF patients exposed to IVT before MT had increased hemorrhagic complications without improved functional outcomes, in contrast with non-AF patients. Prospective trials are warranted to assess whether AF patients represent a subgroup of LVO patients who may benefit from a direct to thrombectomy approach at thrombectomy capable centers.
Keyphrases
- atrial fibrillation
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- acute ischemic stroke
- magnetic resonance
- heart failure
- clinical trial
- magnetic resonance imaging
- pulmonary embolism
- type diabetes
- patient reported outcomes
- acute coronary syndrome
- study protocol
- direct oral anticoagulants
- catheter ablation
- left atrial appendage
- double blind
- placebo controlled