Vortioxetine liposomes as a novel alternative to improve drug stability under stress conditions: toxicity studies and evaluation of antidepressant-like effect.

Caroline Hermann NodariNatália Dalanhol De QuadrosRaquel ChiarentinFrancini Pereira Da SilvaFernando Dal Pont MorissoMariele Feiffer CharãoJuliane Deise FleckCristiane Bastos De MattosAndresa Heemann BettiSimone Gasparin Verza

Published in: Pharmacological reports : PR (2022)

Liposomes seem to be a promising alternative for an oral VXT formulation at lower doses (2.5 mg/kg).

Keyphrases

drug delivery
major depressive disorder
drug release
bipolar disorder
oxidative stress
case control
adverse drug
heat stress