Trim46 knockout impaired neuronal architecture and caused hypoactive behavior in rats.

Feifei GuanShan GaoHanxuan ShengYuanwu MaWei ChenXiaolong QiXu ZhangXiang GaoShuo PangLianfeng ZhangLi Zhang

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2024)

These results demonstrate the significant impact of Trim46 KO on brain structure and behavioral function. This study revealed a novel potential association of TRIM46 with dendritic development and neuropsychiatric behavior, providing new insights into the role of TRIM46 in the brain.

Keyphrases

white matter
cerebral ischemia
resting state
single cell
multiple sclerosis
blood brain barrier
climate change