Effects of Opioid Withdrawal on Psychobiology in People Living with HIV.
Igor GrantEvgeny KrupitskyMarina VetrovaAnya UmlaufRobert K HeatonRichard L HaugerOlga ToussovaDonald R FranklinScott L LetendreGeorge WoodyElena BlokhinaDmitriy A LioznovEdwin E ZvartauPublished in: Viruses (2024)
Worsening of cognition and measures of mood disturbance during withdrawal were associated with activation of the HPA axis and some measures of inflammation. Whether repeated episodes of opioid withdrawal have a cumulative impact on long-term HIV outcomes and neurocognition is a topic for further investigation.
Keyphrases
- chronic pain
- pain management
- antiretroviral therapy
- hiv positive
- human immunodeficiency virus
- oxidative stress
- bipolar disorder
- hepatitis c virus
- hiv aids
- mild cognitive impairment
- type diabetes
- multiple sclerosis
- sleep quality
- white matter
- skeletal muscle
- south africa
- insulin resistance
- physical activity
- weight loss
- glycemic control