Frailty and COVID-19 mRNA Vaccine Antibody Response in the COVID-19 Community Research Partnership.
Charles T SemelkaMichael E DeWittKathryn E CallahanDavid M HerringtonMartha A Alexander-MillerJoshua O YukichIqra MunawarLewis H McCurdyMichael A GibbsWilliam S WeintraubJohn W SandersPublished in: The journals of gerontology. Series A, Biological sciences and medical sciences (2022)
Overall antibody response to COVID-19 mRNA vaccination was high across age and frailty categories. While antibody detection is an incomplete descriptor of vaccine response, the high sensitivity of this antibody combined with health-system data reinforce our conclusions that frailty is an independent predictor of impaired antibody response to the COVID-19 mRNA vaccines. Frailty should be considered in vaccine studies and prevention strategies.