Dosing profiles of concurrent opioid and benzodiazepine use associated with overdose risk among US Medicare beneficiaries: group-based multi-trajectory models.
Wei-Hsuan Lo-CiganicJuan M Hincapie-CastilloTing WangYong GeBobby L JonesJames L HuangChing-Yuan ChangDebbie L WilsonJeannie K LeeGary M ReisfieldChian K KwohChris DelcherKhoa Anh NguyenLili ZhouRonald I ShorrSerena Jingchuan GuoZachary A MarcumChristopher A HarleHaesuk ParkAlmut G WintersteinSeonkyeong YangPei-Lin HuangLauren E AdkinsWalid F GelladPublished in: Addiction (Abingdon, England) (2022)
Patterns of concurrent opioid and benzodiazepine use most associated with overdose risk among fee-for-service US Medicare beneficiaries initiating opioid prescriptions include very high-dose opioid use (MME > 150), high-dose benzodiazepine use (DME > 40) or medium-dose opioid with low-dose benzodiazepine use.