Development of a simple and miniaturized sandwich-like fluorescence polarization assay for rapid screening of SARS-CoV-2 main protease inhibitors.

Gangan YanDongsheng LiYuan LinZhenghao FuHaiyan QiXiaoping LiuJing ZhangShuyi SiYunyu Chen

Published in: Cell & bioscience (2021)

This innovative sandwich-like FP screening assay enables the rapid discovery of antiviral agents targeting viral proteases, and dieckol will be an excellent lead compound for generating more potent and selective antiviral agents targeting SARS-CoV-2 Mpro.

Keyphrases

sars cov
high throughput
respiratory syndrome coronavirus
cancer therapy
loop mediated isothermal amplification
small molecule
single molecule
anti inflammatory
quantum dots