Lung injury does not aggravate mechanical ventilation-induced early cerebral inflammation or apoptosis in an animal model.
Jens KamufAndreas Garcia-BardonAlexander ZiebartRainer ThomasKonstantin FolkertKatrin FrauenknechtSerge Christian ThalErik K HartmannPublished in: PloS one (2018)
With our data we can confirm earlier results, that mechanical ventilation itself seems to trigger cerebral inflammation. This is not aggravated by acute lung injury, at least not within the first 6 hours after onset. Nevertheless, it seems too early to dismiss the idea of lung-injury induced cerebral inflammation, as 6 hours might be just not enough time to see any profound effect.
Keyphrases
- mechanical ventilation
- oxidative stress
- diabetic rats
- acute respiratory distress syndrome
- intensive care unit
- subarachnoid hemorrhage
- high glucose
- respiratory failure
- cerebral ischemia
- extracorporeal membrane oxygenation
- drug induced
- endoplasmic reticulum stress
- brain injury
- big data
- machine learning
- intellectual disability
- cell cycle arrest
- stress induced