Transcription factors CP2 and YY1 as prognostic markers in head and neck squamous cell carcinoma: analysis of The Cancer Genome Atlas and a second independent cohort.
Julia SchnoellBernhard J JankLorenz Kadletz-WankeStefan StoiberClemens P SpielvogelElisabeth GurnhoferLukas KennerGregor HeiduschkaPublished in: Journal of cancer research and clinical oncology (2020)
Our data indicate that simultaneous expression of YY1 and CP2 mRNA is associated with shorter overall survival. Thus, combined high mRNA expression might be a suitable prognostic marker for risk stratification in HNSCC patients. However, since we could not validate this finding at genomic or protein level, we hypothesize that unknown underlying mechanisms which regulate mRNA transcription of YY1 and CP2 are the actual culprits leading to a worse survival.
Keyphrases
- transcription factor
- binding protein
- end stage renal disease
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- papillary thyroid
- prognostic factors
- free survival
- electronic health record
- machine learning
- small molecule
- big data
- patient reported outcomes
- copy number
- artificial intelligence
- protein protein
- deep learning
- data analysis
- genome wide identification